Two pathogenic mechanisms have been proposed for the COVID-19 and GBS associations. After eight weeks of symptoms, there was an increase in serum IgG levels and a reduction in IgM, corroborating the serological pattern for SARS-CoV2 infection. The diagnosis of COVID-19 was confirmed with positive IgG and IgM in the third week after the initial symptoms. There was no positive polymerase chain reaction (PCR) or serology positive findings in the CSF. Since several pathogens can trigger GBS, such as bacteria and viruses, excluding these infections is essential. Also, imaging demonstrated the involvement of the olfactory, oculomotor, trigeminal, abducens, and facial nerves indicating multiple cranial inflammatory neuropathies.ĬSF fluid can show the classic albumin-cytologic dissociation, which reflects the CSF findings, demonstrating an elevation of protein level (231,3 mg/dL in the case) and a negative white cell count. MRI could support the diagnosis: the spinal root involvement was present, with thickening and intense gadolinium enhancement of anterior and posterior spinal roots, compatible with inflammatory radiculopathy. Electroneuromyography confirms the GBS subtype, in which our case demonstrates acute inflammatory demyelinating polyradiculoneuropathy. The patients present symmetrical ascending motor manifestations with or without sensitive or cranial nerves involvement. GBS diagnosis depends on the clinical picture, electrophysiological and CSF analysis. However, the pediatric age group involvement is rare, with few reports in the literature. Guillain-Barré syndrome (GBS) has been reported in association with Coronavirus disease-2019 (COVID-19) in several cases, mainly in adults.
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